Endocrine Abstracts

Introduction: Hyperglycaemia occurs frequently in catecholamine-secreting tumours due to insulin suppression or induced insulin resistance. These changes can be reversible postoperatory (postOp).Objective: Our study aims to establish the impact of surgery in patients with catecholamine-secreting tumours upon glucose metabolism disorders, as well as the predictive factors for postOp diabetes-free patients.Methods: We retrospectively...

Background: There are only few reports regarding the role of serum galectin-3 (Gal-3) as an early biochemical marker in thyroid carcinoma.Aim: To evaluate the potential overexpression of Gal-3 in sera from patients with confirmed diagnosis of papillary thyroid carcinoma (PTC).Patients and methods: We retrospectively investigated serum Gal-3 in 40 patients referred to the surgical department for thyroidectomy. Sera were collected be...

Introduction: Pheochromocytomas are rarely malignant, defined by the presence of cathecholamine – producing metastases. Malignant pheochromocytoma responds poorly to chemotherapy and radiotherapy. 131I-MIBG therapy can be used to prolong survival, with minor side effects.Case: A 45-years old woman known with malignant pheochromocytoma, with a long medical history, first came to our clinic in July 2012. Her diagnosis was suspected in 1999 ...

In pheochromocytoma, intense lypolitic activity may lead to altered lipid profile, which can reverse after tumour removal.Aim: In this study, we evaluated before and at 3 months after surgery for a cathecholamine secreting tumour, a group of 19 patients diagnosed with pheochromocytoma (17) or paraganglioma (2).Patients and methods: 13 women and 6 men, aged 53.68±12.75 years (36–75), presented with a clinical picture of pa...

Objective: The best biochemical strategy to follow in pheochromocytoma clinical diagnosis.Patients and methods: We selected two groups of patients: 24 pheochromocytomas (further diagnosed by CT): 20 women and 4 men aged 20–68 years and a normotensive group: 100 subjects without endocrine disfunction: 83 women and 17 men aged 19–70 years. In both groups we tested five parameters: plasma normetanephrines/metanephrines (NMNp/MNp); urine normetanep...

Objective: To introduce the best biochemical strategy for carcinoid syndrome diagnosis.Patients and methods: We selected two groups of patients: one group of 75 patients suspected of carcinoid syndrome: 57 women aged between 19 and 78 years and 18 men aged 17–81 years and a 80 healthy subjects group without endocrine disfunction: 56 women aged between 27 and 78 years and 24 men aged 17–81 years. We established median values for all parameters i...

A 50–year-old female with a 2 year-history of hypertension and diabetes was admitted to a county hospital, where treatment with clonidine and beta-blockers was started, without success. Abdominal CT showed a large left adrenal tumour, and her initial blood pressure (BP) was over 300/170 mmHg, which dropped to 80/30 mmHg. She was transferred for evaluation of a possible pheochromocytoma (PHEO). At admission her BP was 260/160 mmHg, heart rate (HR) 120 bpm, with anxiety, di...

Introduction: 17th European Congress of Endocrinology 2015. The skeleton health is reflected by the turnover markers as serum CrossLaps (CL=bone resorption), and serum osteocalcin (OC=bone formation), and by the calcium metabolism parameters (as ionic blood calcium, and, probably, by the 24-h urinary calcium=24-h ca). The peripheral serotonin might have intra-normal levels in patients with osteoporosis but yet represents a part of the complex equation related to the bone homeo...

We present a rare association of ovarian carcinoid and virilization. A 65-year-old woman presented with a 9 years history of obesity, hypertension, dyslipidemia, stable angina, evaluated ambulatory for a postmenopausal virilization syndrome and flushes, with high testosterone and 17-hydroxyprogesterone (17OHP) levels without suppression during the 2×2 mg DXM test, normal gynecological evaluations with no tumor formation involving uterus, ovaries and adrenals at the pelvic...